Aberrant metal binding by prion protein in human prion disease
نویسندگان
چکیده
منابع مشابه
Aberrant metal binding by prion protein in human prion disease.
Human prion diseases are characterized by the conversion of the normal prion protein (PrP(C)) into a pathogenic isomer (PrP(Sc)). Distinct PrP(Sc) conformers are associated with different subtypes of prion diseases. PrP(C) binds copper and has antioxidation activity. Changes in metal-ion occupancy can lead to significant decline of the antioxidation activity and changes in conformation of the p...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2001
ISSN: 0022-3042
DOI: 10.1046/j.1471-4159.2001.00522.x